Controlling Self‐Sorting versus Co‐assembly in Supramolecular Gels

Anion-switchable supramolecular gels for controlling pharmaceutical crystal growth.

We describe the use of low-molecular-weight supramolecular gels as media for the growth of molecular crystals. Growth of a range of crystals of organic compounds, including pharmaceuticals, was achieved in bis(urea) gels. Low-molecular-weight supramolecular gelators allow access to an unlimited range of solvent systems, in contrast to conventional aqueous gels such as gelatin and agarose. A det...

How should multicomponent supramolecular gels be characterised?

Low molecular weight gels, or supramolecular gels, are formed when small molecules self-assemble into fibrous structures. Above a critical concentration, the entanglement and cross-linking of these structures leads to the formation of a self-supporting gel. There are many examples where a single component is used to form such gels. There is however an ever-increasing interest in using multiple ...

Controlling monomer-sequence using supramolecular templates

The monomer sequences in biopolymers such as nucleic acids and proteins are strongly linked to their function, and even small errors can yield non-functional macromolecules, or worse. Nature therefore expends significant resources on the (nearly) flawless synthesis of these polymers. For example, DNA is replicated using DNA polymerases, which achieve error rates as low as 1 in 10 nucleotide add...

Controlling molecular tautomerism through supramolecular selectivity.

We have isolated the stable as well as the metastable tautomers of 1-deazapurine in the solid state by exploiting principles of supramolecular selectivity in the context of cocrystal design.

Functional Polymer Gels by Click- and Supramolecular Chemistry